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Claidex MCP

ssatanis/claidex-sentinel

Connects Claude to Claidex's failure intelligence database covering terminated clinical trials across oncology, neurology, and immunology. You get programmatic access to their Claims, which are sourced post-mortems tracing failed drug programs from original hypothesis through preclinical evidence to the mechanistic breakdown of why trials stopped. Useful when you're doing translational research, evaluating target validation, or need to surface why a specific pathway or mechanism didn't pan out in humans. The platform tracks over hundreds of terminated trials with full source citations back to primary literature. Reach for this when you need more than ClinicalTrials.gov entries and want the mechanistic context that rarely makes it into published papers.

tools
24
auth
Secret needed
transport
STDIO, HTTP
env vars
2
last updated
May 24, 2026

Install

From registry metadata
$ npx add-mcp https://app.claidex.com/api/mcp --name failure-intelligence --header 'Authorization: Bearer ${API_TOKEN}'

Run in your terminal. add-mcp asks which agents to add it to, then asks for each value it needs. Add -g to install it for every project.

Review the command, arguments and environment values before installing. MCP servers run with your local permissions.

Other ways

Claude Code

$ claude mcp add --transport http failure-intelligence https://app.claidex.com/api/mcp --header 'Authorization: YOUR_AUTHORIZATION'

Run in your terminal. Add --scope user to make it available in every project.

Tools

Verified live · 24 tools

Verified live against the running server on Nov 6, 2026.

claidex_capabilitiesReturn the Claidex MCP feature map, configured storage/model providers, safety controls, resources, prompts, and tool counts.

Return the Claidex MCP feature map, configured storage/model providers, safety controls, resources, prompts, and tool counts.

No parameters. Call it with no arguments.

claidex_claim_risk_matrixSearch claims and summarize MRS bands, trial phases, failure archetypes, and high-risk programs for rapid diligence.2 params

Search claims and summarize MRS bands, trial phases, failure archetypes, and high-risk programs for rapid diligence.

Parameters* required
limit*integer
default: 10
query*string
Drug, target, disease, sponsor, or failure archetype.
claidex_health_snapshotReturn Sentinel metrics, coverage, graph counts, recent automation runs, MRS bands, and preprint-watch summaries.

Return Sentinel metrics, coverage, graph counts, recent automation runs, MRS bands, and preprint-watch summaries.

No parameters. Call it with no arguments.

claidex_research_promptCompose a rigorous, reusable investigation prompt that tells an MCP client which Claidex tools and resources to use.4 params

Compose a rigorous, reusable investigation prompt that tells an MCP client which Claidex tools and resources to use.

Parameters* required
diseasestring
Optional disease area.
objective*string
The investigation objective to turn into a reusable MCP prompt.
risk_tolerance*string
one of low · medium · highdefault: medium
target_genestring
Optional HGNC target symbol.
claidex_tool_catalogReturn the complete MCP tool catalog, optionally including full input schemas and filtering native versus agent-backed tools.2 params

Return the complete MCP tool catalog, optionally including full input schemas and filtering native versus agent-backed tools.

Parameters* required
include_schemas*boolean
Include full JSON Schemas in the catalog.default: false
source*string
one of all · claidex-agent · mcp-nativedefault: all
consult_specialist_modelAsk a specialist Gateway model for code, database/tool-calling, statistics, literature, preprint, or mechanistic synthesis support. Use for hard subproblems, second opinions, code generation/review, or complex synthesis.3 params

Ask a specialist Gateway model for code, database/tool-calling, statistics, literature, preprint, or mechanistic synthesis support. Use for hard subproblems, second opinions, code generation/review, or complex synthesis.

Parameters* required
contextstring
Relevant context, snippets, or data. Do not include secrets.
prompt*string
Focused task for the specialist model.
task_type*string
Specialist routing target.one of code · database · reasoning · statistics · research · literature
fetchFetch a specific result returned by search. This compatibility tool supports OpenAI and ChatGPT remote MCP retrieval flows.1 params

Fetch a specific result returned by search. This compatibility tool supports OpenAI and ChatGPT remote MCP retrieval flows.

Parameters* required
id*string
Result id returned by the search tool.
fetch_research_urlFetch a public HTTPS research URL, JSON API response, package metadata endpoint, documentation page, or dataset preview. Blocks private/internal hosts and truncates large responses.2 params

Fetch a public HTTPS research URL, JSON API response, package metadata endpoint, documentation page, or dataset preview. Blocks private/internal hosts and truncates large responses.

Parameters* required
max_chars*number
default: 8000
url*string
Public HTTPS URL to fetch.
get_claim_contentRetrieve the complete text content of a specific Claidex Claim by its slug. Use this when you need to read the full post-mortem analysis, including hypothesis, failure mechanism, and prevention analysis.1 params

Retrieve the complete text content of a specific Claidex Claim by its slug. Use this when you need to read the full post-mortem analysis, including hypothesis, failure mechanism, and prevention analysis.

Parameters* required
slug*string
The Claidex claim slug, e.g. exicorilant-mcrpc-gr-bypass-fourth-failure
query_chemblLook up a drug or compound in ChEMBL. Returns mechanism of action, primary target, ChEMBL ID, max development phase, molecular type, and synonyms.1 params

Look up a drug or compound in ChEMBL. Returns mechanism of action, primary target, ChEMBL ID, max development phase, molecular type, and synonyms.

Parameters* required
drug_name*string
Drug or compound name
query_clinicaltrialsSearch ClinicalTrials.gov for clinical trials. Can search by drug name, condition, target, or NCT ID. Returns trial status, phase, sponsor, primary endpoints, and why_stopped if terminated.4 params

Search ClinicalTrials.gov for clinical trials. Can search by drug name, condition, target, or NCT ID. Returns trial status, phase, sponsor, primary endpoints, and why_stopped if terminated.

Parameters* required
max_results*number
default: 5
phase*string
one of PHASE1 · PHASE2 · PHASE3 · PHASE4 · anydefault: any
query*string
Search term: drug name, condition, NCT ID, or target
status*string
one of RECRUITING · ACTIVE_NOT_RECRUITING · TERMINATED · WITHDRAWN · COMPLETED · anydefault: any
query_failure_graphQuery the Claidex failure graph for a specific gene target. Returns the Mechanism Risk Score (MRS), failure counts by phase and archetype, and all related claim slugs.1 params

Query the Claidex failure graph for a specific gene target. Returns the Mechanism Risk Score (MRS), failure counts by phase and archetype, and all related claim slugs.

Parameters* required
target_gene*string
HGNC gene symbol, e.g. PIK3CA, KRAS, EGFR
query_openfdaQuery the FDA FAERS database for adverse event signals for a drug. Returns top adverse event terms, serious case count, and death count.2 params

Query the FDA FAERS database for adverse event signals for a drug. Returns top adverse event terms, serious case count, and death count.

Parameters* required
drug_name*string
Drug name as it appears in FAERS
max_results*number
default: 10
query_opentargetsQuery Open Targets for target-disease association evidence. Returns genetic evidence score, clinical evidence, known drugs, tractability, and safety liabilities for a gene-disease pair.2 params

Query Open Targets for target-disease association evidence. Returns genetic evidence score, clinical evidence, known drugs, tractability, and safety liabilities for a gene-disease pair.

Parameters* required
disease_term*string
Disease name or EFO term
target_gene*string
HGNC gene symbol
query_package_registryLook up package metadata from npm or PyPI before recommending code, analysis packages, API clients, or dataset tooling.2 params

Look up package metadata from npm or PyPI before recommending code, analysis packages, API clients, or dataset tooling.

Parameters* required
ecosystem*string
Package registry to query.one of npm · pypi
package_name*string
Package name.
rank_documents_by_embeddingEmbed a query and candidate documents, then rank documents by cosine similarity. Use for semantic matching, retrieval checks, clustering triage, and lightweight RAG over user-provided passages.3 params

Embed a query and candidate documents, then rank documents by cosine similarity. Use for semantic matching, retrieval checks, clustering triage, and lightweight RAG over user-provided passages.

Parameters* required
documents*array
query*string
top_k*number
default: 10
rerank_documentsRerank candidate documents/passages against a query using a dedicated reranking model. Use after retrieval/search when exact relevance ordering matters.3 params

Rerank candidate documents/passages against a query using a dedicated reranking model. Use after retrieval/search when exact relevance ordering matters.

Parameters* required
documents*array
query*string
top_n*number
default: 10
run_computationEvaluate deterministic mathematical expressions with optional variables. Use for algebra, matrices, vectors, transformations, descriptive numerical checks, and reproducible calculations. Does not execute arbitrary JavaScript or install packages.2 params

Evaluate deterministic mathematical expressions with optional variables. Use for algebra, matrices, vectors, transformations, descriptive numerical checks, and reproducible calculations. Does not execute arbitrary JavaScript or install packages.

Parameters* required
expression*string
MathJS expression, e.g. mean(values), std(values), multiply(A, b), inv(A).
variables*object
Variables available to the expression. Values must be numbers, strings, vectors, or matrices.
run_statistical_analysisRun a statistical analysis computation. Supports: Wilson confidence intervals, binomial proportions, phase transition success rates, power calculations, Bayesian posterior estimates, descriptive statistics, and two-proportion comparisons. Returns computed values, interpretatio...3 params

Run a statistical analysis computation. Supports: Wilson confidence intervals, binomial proportions, phase transition success rates, power calculations, Bayesian posterior estimates, descriptive statistics, and two-proportion comparisons. Returns computed values, interpretatio...

Parameters* required
analysis_type*string
one of wilson_ci · phase_transition_rate · power_calculation · bayesian_posterior · descriptive_stats · failure_rate_comparison
contextstring
Optional context about what this analysis is for
inputs*object
Named input parameters. wilson_ci: {successes, n, confidence}. phase_transition_rate: {phase, indication, n_succeeded, n_total}. power_calculation: {n, effect_size, alpha}. bayesian_posterior: {pri...
searchSearch Claidex failure claims and preprint flags. This compatibility tool returns citation-ready results for OpenAI and ChatGPT remote MCP flows.2 params

Search Claidex failure claims and preprint flags. This compatibility tool returns citation-ready results for OpenAI and ChatGPT remote MCP flows.

Parameters* required
limit*integer
default: 8
query*string
Biomedical failure intelligence query.
search_claimsSearch the Claidex failure database for post-mortems matching a drug name, gene target, disease, failure archetype, or sponsor. Returns matching claims with title, slug, drug, target, disease, phase, failure archetype, Open Targets score, and MRS score.4 params

Search the Claidex failure database for post-mortems matching a drug name, gene target, disease, failure archetype, or sponsor. Returns matching claims with title, slug, drug, target, disease, phase, failure archetype, Open Targets score, and MRS score.

Parameters* required
category*string
one of Oncology · Cardiology · Neurology · Immunology · Infectious Disease · Metabolicdefault: any
failure_archetype*string
one of efficacy_failure · safety_signal · enrollment_collapse · sponsor_decision · strategic_reprioritization · translational_mismatchdefault: any
limit*number
default: 10
query*string
Search term: drug name, gene symbol, disease, or failure archetype
search_preprint_flagsSearch the Claidex Preprint Watch database for bioRxiv preprints flagged as contradicting the clinical failure record. Search by target gene, disease, or preprint title.2 params

Search the Claidex Preprint Watch database for bioRxiv preprints flagged as contradicting the clinical failure record. Search by target gene, disease, or preprint title.

Parameters* required
query*string
Search term: gene symbol, disease, or preprint title fragment
severity*string
one of STRONG · MODERATE · MILD · anydefault: any
search_pubmedSearch PubMed for biomedical literature. Returns title, authors, journal, year, DOI, abstract, and PMID for each result.2 params

Search PubMed for biomedical literature. Returns title, authors, journal, year, DOI, abstract, and PMID for each result.

Parameters* required
max_results*number
default: 5
query*string
PubMed search query
web_searchSearch the web for recent news, investor commentary, analyst notes, press releases, and conference coverage about drugs, clinical trials, or biomedical mechanisms.2 params

Search the web for recent news, investor commentary, analyst notes, press releases, and conference coverage about drugs, clinical trials, or biomedical mechanisms.

Parameters* required
focus*string
one of news · academic · investor · anydefault: any
query*string
Search query

Sponsors

Configuration

CLAIDEX_MCP_URLdefault: https://app.claidex.com/api/mcp

Claidex MCP endpoint URL.

CLAIDEX_MCP_API_KEY*secret

Claidex API key for protected tools and resources.

Readme

Details

Repository
github.com/ssatanis/claidex-sentinel
Website
claidex.com
Package
@claidex-mcp/claidex-mcp
Transport
STDIO, HTTP
Auth
Required
Registry
MCP registry, active
Resources
5
Prompts
5
Tools verified
Nov 6, 2026