Bioinformatics Fundamentals
If you're working with sequencing data or genome assemblies, this gives Claude the context it needs to actually help. It covers SAM/BAM formats, AGP files, quality metrics like MAPQ and PHRED scores, and different sequencing technologies (PacBio HiFi, Hi-C, Illumina). The skill has seen decent uptake with 270 installs, probably because debugging empty BAM outputs or broken read pairs is way easier when the AI knows what paired-end data actually means. It also includes specifics on GenomeArk QC data access, which is niche but exactly the kind of domain knowledge that makes the difference between useful responses and generic advice. Worth adding if bioinformatics is part of your regular workflow.
- skills.sh installs
- 446
- GitHub stars
- 23
- last updated
- Aug 21, 2026
Install
$ npx -y skills add delphine-l/claude_global --skill bioinformatics-fundamentals --agent claude-codeInstalls into .claude/skills of the current project.
Files
Bioinformatics Fundamentals
Foundation knowledge for genomics and bioinformatics workflows. Provides essential understanding of file formats, sequencing technologies, and common data processing patterns.
When to Use This Skill
- Working with sequencing data (PacBio HiFi, Hi-C, Illumina)
- Debugging SAM/BAM alignment or filtering issues
- Processing AGP files for genome assembly curation
- Validating AGP coordinate systems and unloc assignments
- Understanding paired-end vs single-end data
- Interpreting quality metrics (MAPQ, PHRED scores)
- Troubleshooting empty outputs or broken read pairs
- Accessing GenomeArk QC data (GenomeScope, BUSCO, Merqury)
- Curating karyotype data or chromosome count analysis
- General bioinformatics data analysis
SAM/BAM Format Essentials
SAM Flags (Bitwise)
Flags are additive - a read can have multiple flags set simultaneously.
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- Repository
- github.com/delphine-l/claude_global
- Categories
- Code Review & Quality, Data Science & ML, Debugging
- First seen
- Jun 3, 2026
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