Tooluniverse Gwas Drug Discovery
This connects GWAS hits to actual drug targets by doing the full chain: variant to gene (via fine-mapping and eQTL), gene to druggable protein (via OpenTargets tractability), protein to existing compounds (via ChEMBL and DGIdb). The workflow is smart about the causal direction problem: a loss-of-function variant protecting against disease means you want an inhibitor, not an agonist. It includes a composite scoring system weighing genetic evidence, druggability, clinical data, and novelty. The documentation is unusually good about parameter gotchas (ensemblId vs ensemblID, disease_trait not trait). Best for target validation when you have genetic evidence and want to skip straight to what's druggable and whether something already exists for repurposing.
- skills.sh installs
- 388
- GitHub stars
- 1.8K
- last updated
- Aug 21, 2026
Install
$ npx -y skills add mims-harvard/tooluniverse --skill tooluniverse-gwas-drug-discovery --agent claude-codeInstalls into .claude/skills of the current project.
Files
GWAS-to-Drug Target Discovery
Transform genome-wide association studies (GWAS) into actionable drug targets and repurposing opportunities.
IMPORTANT: Always use English terms in tool calls. Respond in the user's language.
Overview
This skill bridges genetic discoveries from GWAS with drug development by:
- Identifying genetic risk factors - Finding genes associated with diseases
- Assessing druggability - Evaluating which genes can be targeted by drugs
- Prioritizing targets - Ranking candidates by genetic evidence strength
- Finding existing drugs - Discovering approved/investigational compounds
- Identifying repurposing opportunities - Matching drugs to new indications
Key insight: Targets with genetic support have 2x higher probability of clinical approval (Nelson et al., Nature Genetics 2015).
Reasoning Strategy
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- Repository
- github.com/mims-harvard/tooluniverse
- Categories
- Data Science & ML, Sales & Marketing
- First seen
- Jun 3, 2026
More from mims-harvard/tooluniverse
All 68- Devtu Optimize Descriptions385
- Tooluniverse Drug Target Validation384
- Tooluniverse Infectious Disease384
- Devtu Auto Discover Apis383
- Tooluniverse Cancer Variant Interpretation382
- Devtu Fix Tool380
- Tooluniverse Precision Medicine Stratification377
- Tooluniverse Gwas Snp Interpretation376
- Tooluniverse Crispr Screen Analysis375
- Tooluniverse Structural Variant Analysis374
- Tooluniverse Variant Analysis373
- Tooluniverse Adverse Event Detection371
- Devtu Github365
- Tooluniverse Gwas Trait To Gene365
- Tooluniverse Phylogenetics365
- Tooluniverse Gwas Finemapping364
- Tooluniverse Spatial Omics Analysis363
- Tooluniverse Immunotherapy Response Prediction362
- Tooluniverse Immune Repertoire Analysis361
- Tooluniverse Install Skills361
- Tooluniverse Multiomic Disease Characterization360
- Tooluniverse Gwas Study Explorer359
- Tooluniverse Metabolomics358
- Tooluniverse Variant Interpretation353
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