If you're doing single-cell analysis with deep learning, this is your toolkit. It covers the scvi-tools ecosystem: scVI for batch correction, scANVI for label transfer, totalVI for CITE-seq, MultiVI for multiome data, and DestVI for spatial deconvolution. The skill includes workflow-specific reference files and CLI scripts that handle the tedious bits like data prep and clustering. The main thing to know is that these models need raw counts, not normalized data, and you'll want to select highly variable genes first. The decision tree alone saves you from reading through model papers to figure out which one fits your data type.

skills.sh installs
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GitHub stars
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last updated
Aug 21, 2026

Install

$ npx -y skills add anthropics/knowledge-work-plugins --skill scvi-tools --agent claude-code

Installs into .claude/skills of the current project.

Files

scvi-tools Deep Learning Skill

This skill provides guidance for deep learning-based single-cell analysis using scvi-tools, the leading framework for probabilistic models in single-cell genomics.

How to Use This Skill

  1. Identify the appropriate workflow from the model/workflow tables below
  2. Read the corresponding reference file for detailed steps and code
  3. Use scripts in scripts/ to avoid rewriting common code
  4. For installation or GPU issues, consult references/environment_setup.md
  5. For debugging, consult references/troubleshooting.md

When to Use This Skill

  • When scvi-tools, scVI, scANVI, or related models are mentioned
  • When deep learning-based batch correction or integration is needed
  • When working with multi-modal data (CITE-seq, multiome)
  • When reference mapping or label transfer is required
  • When analyzing ATAC-seq or spatial transcriptomics data
  • When learning latent representations of single-cell data

Model Selection Guide

Sponsors

Details

Repository
github.com/anthropics/knowledge-work-plugins
Category
Automation & Workflows
First seen
May 16, 2026

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