Gnomad Database

This is a wrapper for querying the gnomAD database, which contains genetic variant data used in genomics research. It enforces API rate limits automatically through helper scripts, so you don't hammer the Broad Institute's servers while pulling down variant frequencies or population genetics data. The skill requires uv and makes you acknowledge the gnomAD terms of service before first use, which is reasonable given you're accessing a major scientific database. If you're doing any work with human genetic variants, allele frequencies, or clinical genomics, this gives you programmatic access without writing your own rate limiting logic. Part of DeepMind's science skills collection, which explains the research focus.

skills.sh installs: 2.2K
GitHub stars: 3.4K
last updated: Aug 21, 2026

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Install

$ npx -y skills add google-deepmind/science-skills --skill gnomad-database --agent claude-code

Installs into .claude/skills of the current project.

Files

gnomAD Database

Prerequisites

uv: Read the uv skill and follow its Setup instructions to ensure uv is installed and on PATH.
User Notification: If .licenses/gnomad_database_LICENSE.txt does not already exist in the workspace root directory then (1) prominently notify the user to check the terms at https://gnomad.broadinstitute.org/policies and https://gnomad.broadinstitute.org/data#api, then (2) create the file recording the notification text and timestamp.

Core Rules

Use the Wrapper: ALWAYS execute the provided helper scripts to query the database rather than accessing the database directly. The scripts automatically enforce the gnomAD API rate limits gracefully.
Notification: If this skill is used, ensure this is mentioned in the output.

Utility Scripts

All scripts are located in the scripts/ subdirectory of this skill's installation directory. When running them, use the full absolute path to the script (e.g. /path/to/gnomad_database/scripts/get_variant_frequency.py).

SKILL.md on GitHub