Jaspar Database

This is a straightforward interface to JASPAR, the go-to open-access database for transcription factor binding profiles. You feed it sequence motifs or genomic coordinates and it tells you what transcription factors bind there, or you can go the other direction and look up the motif for a specific TF like CTCF. It's part of Google DeepMind's science-skills collection and requires uv to be installed. The skill handles license notification on first use, which is a nice touch since you're hitting their API. If you're doing any kind of gene regulation work or need to interpret ChIP-seq peaks, this saves you from manually querying the JASPAR website.

skills.sh installs: 2.2K
GitHub stars: 3.4K
last updated: Aug 21, 2026

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Install

$ npx -y skills add google-deepmind/science-skills --skill jaspar-database --agent claude-code

Installs into .claude/skills of the current project.

Files

JASPAR Skill

JASPAR is the definitive open-access database for Transcription Factor (TF) binding profiles, stored as Position Frequency Matrices (PFMs).

Use this skill to map abstract sequence motifs or genomic regions to specific biological regulators (e.g., "what TFs bind here?" or "what is the motif for CTCF?").

Prerequisites

uv: Read the uv skill and follow its Setup instructions to ensure uv is installed and on PATH.
User Notification: If .licenses/jaspar_database_LICENSE.txt does not already exist in the workspace root directory then (1) prominently notify the user to check the terms at https://jaspar.elixir.no/ and https://jaspar.elixir.no/api/, then (2) create the file recording the notification text and timestamp.