Reactome Database

If you're doing bioinformatics work and need to query pathway data, this wraps Reactome's Analysis and Content Service APIs so you can run pathway enrichment analysis, map identifiers, navigate pathway hierarchies, and pull reaction details without leaving your editor. It's from DeepMind's science-skills collection and has passed security audits from three providers. One heads up: it requires uv to be installed and will prompt you to review Reactome's license terms on first use, creating a local record of that notification. Useful if you're analyzing gene sets or building tools that need curated biological pathway data, though you'll want to be comfortable with the Python tooling dependency.

skills.sh installs: 2.2K
GitHub stars: 3.4K
last updated: Aug 21, 2026

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Install

$ npx -y skills add google-deepmind/science-skills --skill reactome-database --agent claude-code

Installs into .claude/skills of the current project.

Files

Reactome Analysis & Content Service

Prerequisites

uv: Read the uv skill and follow its Setup instructions to ensure uv is installed and on PATH.
User Notification: If .licenses/reactome_database_LICENSE.txt does not already exist in the workspace root directory then (1) prominently notify the user to check the terms at https://reactome.org/license and https://reactome.org/cite, then (2) create the file recording the notification text and timestamp.

Overview

Reactome is a free, open-source, curated pathway database. This skill wraps both the Analysis Service (https://reactome.org/AnalysisService/) and the Content Service (https://reactome.org/ContentService/) providing pathway enrichment analysis, identifier mapping, reaction details, pathway hierarchy navigation, diagram export, cross-reference mapping, and search.